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Research Shows CBD Benefits 50+ Conditions

Over the last few years, Cannabidiol (CBD) has exploded into the world of health and wellness.

With dozens of natural benefits, CBD has been used to ease conditions such as anxietyepilepsyneurodegenerative diseases and more.

For the last century, researchers have assessed CBD as a treatment for numerous conditions. More than 50, in fact.

What these studies show is profound.

If you are looking for research on CBD benefits for a certain condition, you will find it here.

From mental health to MS, we have gathered a collection of more than 250 resources, organized by condition.

Check out the collection below.

Studies Reveal CBD Benefits More Than 50 Conditions

Browse Medical Research Based on Condition

# CONDITION MEDICAL RESEARCH
5 CBD FOR ACNE Cannabidiol as a Treatment for Acne?
CBD FOR ACNE Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
CBD FOR ACNE The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities
CBD FOR ACNE Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
CBD FOR ACNE Endocannabinoid signaling and epidermal differentiation
6 CBD FOR ADD / ADHD Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders
CBD FOR ADD / ADHD Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats
CBD FOR ADD / ADHD Subtypes of Attention Deficit — Hyperactivity Disorder (ADHD) and cannabis use
CBD FOR ADD / ADHD Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students
CBD FOR ADD / ADHD Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: A case report
CBD FOR ADD / ADHD Fitness to drive in spite (because) of THC
10 CBD FOR ADDICTION Cannabidiol reduces cigarette consumption in tobacco smokers
CBD FOR ADDICTION Cannabidiol inhibits the reward-facilitating effect of morphine
CBD FOR ADDICTION Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances
CBD FOR ADDICTION Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats
CBD FOR ADDICTION Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment
CBD FOR ADDICTION Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010
CBD FOR ADDICTION Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
CBD FOR ADDICTION Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity
CBD FOR ADDICTION Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
CBD FOR ADDICTION Cannabidiol for the treatment of cannabis withdrawal syndrome
4 CBD FOR ALS Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials
CBD FOR ALS ALS: delayed disease progression in mice by treatment with a cannabinoid
CBD FOR ALS The (Endo)Cannabinoid System in Multiple Sclerosis and ALS
CBD FOR ALS Survey of cannabis use in patients with ALS
16 CBD FOR ALZHEIMERS The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
CBD FOR ALZHEIMERS Endocannabinoid signalling in Alzheimer’s disease
CBD FOR ALZHEIMERS A molecular link between the active component of marijuana and Alzheimer’s disease pathology
CBD FOR ALZHEIMERS Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
CBD FOR ALZHEIMERS The Potential Therapeutic Effects of THC on Alzheimer’s Disease
CBD FOR ALZHEIMERS The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease
CBD FOR ALZHEIMERS Cannabinoids for the treatment of dementia
CBD FOR ALZHEIMERS Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
CBD FOR ALZHEIMERS Cannabidiol: A promising drug for neurodegenerative disorders?
CBD FOR ALZHEIMERS Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
CBD FOR ALZHEIMERS The role of the endocannabinoid system in Alzheimer’s disease: facts and hypotheses
CBD FOR ALZHEIMERS The role of phytochemicals in the treatment and prevention of dementia
CBD FOR ALZHEIMERS Cannabinoids for the treatment of dementia
CBD FOR ALZHEIMERS Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement
CBD FOR ALZHEIMERS Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
CBD FOR ALZHEIMERS Can Marijuana Prevent Alzheimer’s?
4 CBD FOR ANOREXIA Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa
CBD FOR ANOREXIA The role of the endocannabinoid system in eating disorders: Neurochemical and behavioural preclinical evidence
CBD FOR ANOREXIA Cancer cachexia and cannabinoids
CBD FOR ANOREXIA Brain Type 1 Cannabinoid Receptor Availability in Patients with Anorexia and Bulimia Nervosa
9 CBD FOR ANXIETY Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
CBD FOR ANXIETY Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
CBD FOR ANXIETY Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
CBD FOR ANXIETY Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder
CBD FOR ANXIETY Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
CBD FOR ANXIETY Effects of cannabidiol (CBD) on regional cerebral blood flow
CBD FOR ANXIETY The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors
CBD FOR ANXIETY The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
CBD FOR ANXIETY Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence
4 CBD FOR ATHEROSCLEROSIS The role of the endocannabinoid system in atherosclerosis
CBD FOR ATHEROSCLEROSIS Cannabinoid receptors in atherosclerosis
CBD FOR ATHEROSCLEROSIS The potential use of cannabidiol in the therapy of metabolic syndrome
CBD FOR ATHEROSCLEROSIS Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice
4 CBD FOR ARTHRITIS Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
CBD FOR ARTHRITIS The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
CBD FOR ARTHRITIS The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55
CBD FOR ARTHRITIS Arthritis and cannabinoids
5 CBD FOR ASTHMA The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke
CBD FOR ASTHMA Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
CBD FOR ASTHMA Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs
CBD FOR ASTHMA Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways
CBD FOR ASTHMA Bronchodilator effect of delta1-tetrahydrocannabinol
5 CBD FOR AUTISM Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
CBD FOR AUTISM Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
CBD FOR AUTISM A novel approach to the symptomatic treatment of autism
CBD FOR AUTISM Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders
CBD FOR AUTISM Targeting the endocannabinoid system in the treatment of fragile X syndrome
5 CBD FOR BIPOLAR AFFECTIVE DISORDER Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential
CBD FOR BIPOLAR AFFECTIVE DISORDER Cannabidiol was ineffective for manic episode of bipolar affective disorder
CBD FOR BIPOLAR AFFECTIVE DISORDER Effects of Co-occurring Cannabis Use Disorders on the Course of Bipolar Disorder After a First Hospitalization for Mania
CBD FOR BIPOLAR AFFECTIVE DISORDER Does Cannabis Use Affect Treatment Outcome in Bipolar Disorder?: A Longitudinal Analysis
CBD FOR BIPOLAR AFFECTIVE DISORDER The Use of Cannabis as a Mood Stabilizer in Bipolar Disorder: Anecdotal Evidence and the Need for Clinical Research
5 CBD FOR CANCER – GENERAL Cannabidiol as potential anticancer drug
CBD FOR CANCER – GENERAL Cannabidiol inhibits angiogenesis by multiple mechanisms
CBD FOR CANCER – GENERAL The inhibitory effects of cannabidiol on systemic malignant tumors
CBD FOR CANCER – GENERAL Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
CBD FOR CANCER – GENERAL Marijuana fights cancer and helps manage side effects
4 CBD FOR CANCER – LUNG Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
CBD FOR CANCER – LUNG COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
CBD FOR CANCER – LUNG Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells
CBD FOR CANCER – LUNG Media ignored expert’s shocking findings that marijuana helps prevent lung cancer
5 CBD FOR CANCER – PROSTATE/COLON Towards the use of non-psychoactive cannabinoids for prostate cancer
CBD FOR CANCER – PROSTATE/COLON In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines
CBD FOR CANCER – PROSTATE/COLON Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
CBD FOR CANCER – PROSTATE/COLON Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
CBD FOR CANCER – PROSTATE/COLON Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol
5 CBD FOR CANCER – BREAST Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
CBD FOR CANCER – BREAST Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
CBD FOR CANCER – BREAST Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
CBD FOR CANCER – BREAST Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
CBD FOR CANCER – BREAST Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration
8 CBD FOR CANCER – BRAIN Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
CBD FOR CANCER – BRAIN Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines(PubMed)
CBD FOR CANCER – BRAIN Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
CBD FOR CANCER – BRAIN Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
CBD FOR CANCER – BRAIN Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
CBD FOR CANCER – BRAIN Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
CBD FOR CANCER – BRAIN Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
CBD FOR CANCER – BRAIN Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme
4 CBD FOR CANCER – LEUKEMIA Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
CBD FOR CANCER – LEUKEMIA Cannabidiol-Induced Apoptosis in Human Leukemia Cells
CBD FOR CANCER – LEUKEMIA Cannabidiol Reduces Leukemic Cell Size – But Is It Important?
CBD FOR CANCER – LEUKEMIA Targeting cannabinoid receptors to treat leukemia
4 CBD FOR CANCER – SKIN Anticancer activity of anandamide in human cutaneous melanoma cells
CBD FOR CANCER – SKIN Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium (PubMed)
CBD FOR CANCER – SKIN Cannabinoid receptors as novel targets for the treatment of melanoma
CBD FOR CANCER – SKIN The Cannabinoid Receptors Are Required for Ultraviolet-Induced Inflammation and Skin Cancer Development
4 CBD FOR CANCER – ENDOCRINE Endocannabinoids in endocrine and related tumours
CBD FOR CANCER – ENDOCRINE A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells
CBD FOR CANCER – ENDOCRINE Cannabinoids in pancreatic cancer: Correlation with survival and pain
CBD FOR CANCER – ENDOCRINE Cannabinoid 2 receptor induction by IL-12 and its potential as a therapeutic target for the treatment of anaplastic thyroid carcinoma
4 CBD FOR CANCER – BLADDER TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer
CBD FOR CANCER – BLADDER Association Between Cannabis Use and the Risk of Bladder Cancer
CBD FOR CANCER – BLADDER Inhibitory Effect of Standardized Cannabis sativaExtract and Its Ingredient Cannabidiol on Rat and Human Bladder Contractility
CBD FOR CANCER – BLADDER Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism
4 CBD FOR CANCER – PAIN RELIEF Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
CBD FOR CANCER – PAIN RELIEF Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial
CBD FOR CANCER – PAIN RELIEF Marijuana extract helps prevent chemo pain
CBD FOR CANCER – PAIN RELIEF An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics
10 CBD FOR CROHNS & COLITIS Cannabidiol in inflammatory bowel diseases: a brief overview
CBD FOR CROHNS & COLITIS Cannabis finds its way into treatment of Crohn’s disease
CBD FOR CROHNS & COLITIS Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
CBD FOR CROHNS & COLITIS Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
CBD FOR CROHNS & COLITIS The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
CBD FOR CROHNS & COLITIS Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice
CBD FOR CROHNS & COLITIS Cannabinoids and the gut: New developments and emerging concepts
CBD FOR CROHNS & COLITIS Endocannabinoids and the gastrointestinal tract
CBD FOR CROHNS & COLITIS Cannabinoids and gastrointestinal motility: Animal and human studies
CBD FOR CROHNS & COLITIS Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis
11 CBD FOR DEPRESSION Endocannabinoid system dysfunction in mood and related disorders
CBD FOR DEPRESSION Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
CBD FOR DEPRESSION The endocannabinoid system and the treatment of mood and anxiety disorders
CBD FOR DEPRESSION Endocannabinoid signaling in the etiology and treatment of major depressive illness
CBD FOR DEPRESSION Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors
CBD FOR DEPRESSION Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
CBD FOR DEPRESSION Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa
CBD FOR DEPRESSION Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
CBD FOR DEPRESSION Serum contents of endocannabinoids are correlated with blood pressure in depressed women
CBD FOR DEPRESSION The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants
CBD FOR DEPRESSION Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures
21 CBD FOR ENDOCRINE DISORDERS Endocannabinoid system participates in neuroendocrine control of homeostasis
CBD FOR ENDOCRINE DISORDERS The emerging role of the endocannabinoid system in endocrine regulation and energy balance
CBD FOR ENDOCRINE DISORDERS Endocannabinoids in endocrine and related tumours
CBD FOR ENDOCRINE DISORDERS Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas
CBD FOR ENDOCRINE DISORDERS The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
CBD FOR ENDOCRINE DISORDERS CBD for children with Dravet’s and intractable seizures
CBD FOR ENDOCRINE DISORDERS Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
CBD FOR ENDOCRINE DISORDERS Medicinal marijuana stops seizures, brings hope to a little girl
CBD FOR ENDOCRINE DISORDERS Cannabinoids for epilepsy
CBD FOR ENDOCRINE DISORDERS Cannabis, cannabidiol, and epilepsy – From receptors to clinical response
CBD FOR ENDOCRINE DISORDERS The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability
CBD FOR ENDOCRINE DISORDERS Chronic administration of cannabidiol to healthy volunteers and epileptic patients
CBD FOR ENDOCRINE DISORDERS Endocannabinoid system protects against cryptogenic seizures
CBD FOR ENDOCRINE DISORDERS Seizing an opportunity for the endocannabinoid system
CBD FOR ENDOCRINE DISORDERS Cannabidiol: promise and pitfalls
CBD FOR ENDOCRINE DISORDERS Cannabidivarin (CBDV) suppressespentylenetetrazole (PTZ)-inducedincreases in epilepsy-related gene expression
CBD FOR ENDOCRINE DISORDERS Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
CBD FOR ENDOCRINE DISORDERS Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
CBD FOR ENDOCRINE DISORDERS Hypnotic and antiepileptic effects of cannabidiol
CBD FOR ENDOCRINE DISORDERS The cannabinoids as potential antiepileptics
CBD FOR ENDOCRINE DISORDERS Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats
5 CBD FOR FIBROMYALGIA Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
CBD FOR FIBROMYALGIA Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life
CBD FOR FIBROMYALGIA Association of herbal cannabis use with negative psychosocial parameters in patients with fibromyalgia
CBD FOR FIBROMYALGIA Cannabinoids for fibromyalgia
CBD FOR FIBROMYALGIA Medical Cannabis for the Treatment of Fibromyalgia
4 CBD FOR GLAUCOMA Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
CBD FOR GLAUCOMA Cannabinoids and glaucoma
CBD FOR GLAUCOMA The treatment of glaucoma using a non-psychoactive preparation of Cannabis sativa
CBD FOR GLAUCOMA Cannabinoids for treatment of glaucoma
7 CBD FOR HEART DISEASE Is the cardiovascular system a therapeutic target for cannabidiol?
CBD FOR HEART DISEASE Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
CBD FOR HEART DISEASE Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
CBD FOR HEART DISEASE The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A1 Receptors
CBD FOR HEART DISEASE Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
CBD FOR HEART DISEASE Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
CBD FOR HEART DISEASE Oleamide: A fatty acid amide signaling molecule in the cardiovascular system?
6 CBD FOR HUNTINGTONS DISEASE Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease
CBD FOR HUNTINGTONS DISEASE Cannabinoids: Novel medicines for the treatment of Huntington’s disease
CBD FOR HUNTINGTONS DISEASE Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB(1) and CB(2) receptors
CBD FOR HUNTINGTONS DISEASE Controlled clinical trial of cannabidiol in Huntington’s disease
CBD FOR HUNTINGTONS DISEASE Prospects for cannabinoid therapies in basal ganglia disorders
CBD FOR HUNTINGTONS DISEASE Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice
13 CBD FOR INFLAMMATION Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
CBD FOR INFLAMMATION The endocannabinoid system: an emerging key player in inflammation
CBD FOR INFLAMMATION Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice
CBD FOR INFLAMMATION Cannabinoids, endocannabinoids, and related analogs in inflammation
CBD FOR INFLAMMATION Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
CBD FOR INFLAMMATION Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
CBD FOR INFLAMMATION Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
CBD FOR INFLAMMATION Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
CBD FOR INFLAMMATION Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
CBD FOR INFLAMMATION Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
CBD FOR INFLAMMATION Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
CBD FOR INFLAMMATION Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
CBD FOR INFLAMMATION Cannabinoids in clinical practice
9 CBD FOR IRRITABLE BOWEL SYNDROME Cannabidiol in inflammatory bowel diseases: A brief overview
CBD FOR IRRITABLE BOWEL SYNDROME Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
CBD FOR IRRITABLE BOWEL SYNDROME Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
CBD FOR IRRITABLE BOWEL SYNDROME Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation
CBD FOR IRRITABLE BOWEL SYNDROME Therapeutic potential of cannabinoid-based drugs
CBD FOR IRRITABLE BOWEL SYNDROME Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)
CBD FOR IRRITABLE BOWEL SYNDROME Cannabinoids and the gut: New developments and emerging concepts
CBD FOR IRRITABLE BOWEL SYNDROME Endocannabinoids and the gastrointestinal tract
CBD FOR IRRITABLE BOWEL SYNDROME Cannabinoids and gastrointestinal motility: Animal and human studies
4 CBD FOR KIDNEY DISEASE Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
CBD FOR KIDNEY DISEASE Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay
CBD FOR KIDNEY DISEASE Is There a Legitimate Role for the Therapeutic Use of Cannabinoids for Symptom Management in Chronic Kidney Disease?
CBD FOR KIDNEY DISEASE The emerging role of the endocannabinoid system in the pathogenesis and treatment of kidney diseases
7 CBD FOR LIVER DISEASE The endocannabinoid system and liver diseases
CBD FOR LIVER DISEASE Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death
CBD FOR LIVER DISEASE Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis
CBD FOR LIVER DISEASE Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
CBD FOR LIVER DISEASE Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
CBD FOR LIVER DISEASE Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
CBD FOR LIVER DISEASE Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation
5 CBD FOR METABOLIC SYNDROME The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
CBD FOR METABOLIC SYNDROME The potential use of cannabidiol in the therapy of metabolic syndrome
CBD FOR METABOLIC SYNDROME Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
CBD FOR METABOLIC SYNDROME Metabolic syndrome in people with a psychotic illness: is cannabis protective?
CBD FOR METABOLIC SYNDROME Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome
5 CBD FOR MIGRAINES Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
CBD FOR MIGRAINES Effects of anandamide in migraine: data from an animal model
CBD FOR MIGRAINES Cannabinoids and hallucinogens for headache
CBD FOR MIGRAINES The endocannabinoid system and migraine
CBD FOR MIGRAINES Variations in the cannabinoid receptor 1 gene predispose to migraine
6 CBD FOR MOOD DISORDERS Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
CBD FOR MOOD DISORDERS The endocannabinoid system and the treatment of mood and anxiety disorders
CBD FOR MOOD DISORDERS The endocannabinoid system and psychiatric disorders
CBD FOR MOOD DISORDERS The endocannabinoid system in the regulation of emotions throughout lifespan: A discussion on therapeutic perspectives
CBD FOR MOOD DISORDERS Endocannabinoid system dysfunction in mood and related disorders
CBD FOR MOOD DISORDERS Effects of cannabidiol (CBD) on regional cerebral blood flow
3 CBD FOR MOTION SICKNESS Motion sickness, stress and the endocannabinoid system
CBD FOR MOTION SICKNESS Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system
CBD FOR MOTION SICKNESS The Effects of Cannabidiol and Tetrahydrocannabinol on Motion‐Induced Emesis
10 CBD FOR MULTIPLE SCLEROSIS Sativex for the management of multiple sclerosis symptoms
CBD FOR MULTIPLE SCLEROSIS THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis
CBD FOR MULTIPLE SCLEROSIS Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity
CBD FOR MULTIPLE SCLEROSIS Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
CBD FOR MULTIPLE SCLEROSIS Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial
CBD FOR MULTIPLE SCLEROSIS Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis
CBD FOR MULTIPLE SCLEROSIS Sativex long-term use: An open-label trial in patients with spasticity due to multiple sclerosis
CBD FOR MULTIPLE SCLEROSIS A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis
CBD FOR MULTIPLE SCLEROSIS Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain(
CBD FOR MULTIPLE SCLEROSIS Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
6 CBD FOR NAUSEA Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus
CBD FOR NAUSEA Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
CBD FOR NAUSEA Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
CBD FOR NAUSEA Regulation of nausea and vomiting by cannabinoids
CBD FOR NAUSEA Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats
CBD FOR NAUSEA Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting
5 CBD FOR NEURODEGENERATION Cannabidiol: A promising drug for neurodegenerative disorders?
CBD FOR NEURODEGENERATION Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?
CBD FOR NEURODEGENERATION Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
CBD FOR NEURODEGENERATION Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
CBD FOR NEURODEGENERATION Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection
18 CBD FOR NEUROPATHIC PAIN Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
CBD FOR NEUROPATHIC PAIN Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
CBD FOR NEUROPATHIC PAIN Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine
CBD FOR NEUROPATHIC PAIN Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial
CBD FOR NEUROPATHIC PAIN Cannabinoids for neuropathic pain
CBD FOR NEUROPATHIC PAIN Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue
CBD FOR NEUROPATHIC PAIN Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial
CBD FOR NEUROPATHIC PAIN The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
CBD FOR NEUROPATHIC PAIN Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
CBD FOR NEUROPATHIC PAIN Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
CBD FOR NEUROPATHIC PAIN Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: Mechanisms involved
CBD FOR NEUROPATHIC PAIN Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
CBD FOR NEUROPATHIC PAIN Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
CBD FOR NEUROPATHIC PAIN Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes
CBD FOR NEUROPATHIC PAIN Cannabinoids in the management of difficult to treat pain
CBD FOR NEUROPATHIC PAIN Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
CBD FOR NEUROPATHIC PAIN Marijuana extract helps prevent chemo pain
CBD FOR NEUROPATHIC PAIN Pot users less likely to take painkillers
6 CBD FOR OBESITY The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
CBD FOR OBESITY Cannabinol and cannabidiol exert opposing effects on rat feeding patterns
CBD FOR OBESITY Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?
CBD FOR OBESITY The endocannabinoid system in obesity and type 2 diabetes
CBD FOR OBESITY Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk
CBD FOR OBESITY Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes
3 CBD FOR OCD Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour (PubMed)
CBD FOR OCD Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour
CBD FOR OCD Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice
7 CBD FOR PARKINSONS DISEASE Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
CBD FOR PARKINSONS DISEASE Prospects for cannabinoid therapies in basal ganglia disorders
CBD FOR PARKINSONS DISEASE Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: Importance of antioxidant and cannabinoid receptor-independent properties
CBD FOR PARKINSONS DISEASE Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease
CBD FOR PARKINSONS DISEASE Cannabidiol for the treatment of psychosis in Parkinson’s disease
CBD FOR PARKINSONS DISEASE Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease
CBD FOR PARKINSONS DISEASE Therapeutic potential of cannabinoids in CNS disease
3 CBD FOR PRION Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
CBD FOR PRION Cannabidiol: A prion therapy for mice?
CBD FOR PRION Alteration of the endocannabinoid system in mouse brain during prion disease
13 CBD FOR PTSD The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD
CBD FOR PTSD Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks
CBD FOR PTSD Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
CBD FOR PTSD Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors
CBD FOR PTSD Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis
CBD FOR PTSD Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence
CBD FOR PTSD Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment
CBD FOR PTSD The endocannabinoid system and extinction learning
CBD FOR PTSD A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers
CBD FOR PTSD Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit
CBD FOR PTSD Non-antidepressant long-term treatment in post-traumatic stress disorder
CBD FOR PTSD The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system
CBD FOR PTSD Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors
4 CBD FOR RHEUMATISM Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
CBD FOR RHEUMATISM Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases
CBD FOR RHEUMATISM Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
CBD FOR RHEUMATISM Cannabinoids in the Management of Musculoskeletal or Rheumatic Diseases
12 CBD FOR SCHIZOPHRENIA Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
CBD FOR SCHIZOPHRENIA Cannabidiol as a potential treatment for psychosis
CBD FOR SCHIZOPHRENIA Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
CBD FOR SCHIZOPHRENIA Medical use of cannabis. Cannabidiol: A new light for schizophrenia?
CBD FOR SCHIZOPHRENIA A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation
CBD FOR SCHIZOPHRENIA Peripheral endocannabinoid system dysregulation in first-episode psychosis
CBD FOR SCHIZOPHRENIA Cannabinoids and schizophrenia: Therapeutic prospects
CBD FOR SCHIZOPHRENIA Antipsychotic-like effects of cannabidiol and rimonabant: Systematic review of animal and human studies
CBD FOR SCHIZOPHRENIA Cannabidiol monotherapy for treatment-resistant schizophrenia
CBD FOR SCHIZOPHRENIA Cannabis with high cannabidiol content is associated with fewer psychotic experiences
CBD FOR SCHIZOPHRENIA Marijuana compound treats schizophrenia with few side effects: Clinical trial
CBD FOR SCHIZOPHRENIA Clearing the smoke: what do we know about adolescent cannabis use and schizophrenia?
3 CBD FOR SICKLE CELL ANEMIA Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids
CBD FOR SICKLE CELL ANEMIA Cannabis use in sickle cell disease: A questionnaire study
CBD FOR SICKLE CELL ANEMIA Cannabinoid Receptor-Specific Mechanisms To Alleviate Pain In Sickle Cell Anemia Via Inhibition Of Mast Cell Activation And Neurogenic Inflammation
8 CBD FOR SKIN CONDITIONS Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis
CBD FOR SKIN CONDITIONS Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
CBD FOR SKIN CONDITIONS The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities
CBD FOR SKIN CONDITIONS Epigenetic control of skin differentiation genes by phytocannabinoids
CBD FOR SKIN CONDITIONS Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1
CBD FOR SKIN CONDITIONS Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation
CBD FOR SKIN CONDITIONS Attenuation of allergic contact dermatitis through the endocannabinoid system
CBD FOR SKIN CONDITIONS Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus
7 CBD FOR SLEEP DISORDERS The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent
CBD FOR SLEEP DISORDERS Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine
CBD FOR SLEEP DISORDERS Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats
CBD FOR SLEEP DISORDERS Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
CBD FOR SLEEP DISORDERS Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats
CBD FOR SLEEP DISORDERS Endocannabinoid modulation of cortical up-states and NREM sleep
CBD FOR SLEEP DISORDERS Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat
4 CBD FOR SPINAL CORD INJURY Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury
CBD FOR SPINAL CORD INJURY Cannabis effect on spasticity in spinal cord injury
CBD FOR SPINAL CORD INJURY An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease
CBD FOR SPINAL CORD INJURY Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonist after Spinal Cord Injury
13 CBD FOR STRESS Endogenous cannabinoid signaling is essential for stress adaptation
CBD FOR STRESS Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders
CBD FOR STRESS Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output
CBD FOR STRESS Neuromodulators, stress and plasticity: a role for endocannabinoid signalling
CBD FOR STRESS Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
CBD FOR STRESS Endocannabinoids and stress
CBD FOR STRESS Stress regulates endocannabinoid-CB1 receptor signaling
CBD FOR STRESS Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus
CBD FOR STRESS Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance
CBD FOR STRESS Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression
CBD FOR STRESS Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory
CBD FOR STRESS The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
CBD FOR STRESS Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid
6 CBD FOR STROKE/TBI Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
CBD FOR STROKE/TBI Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
CBD FOR STROKE/TBI Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism (
CBD FOR STROKE/TBI Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
CBD FOR STROKE/TBI Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice
CBD FOR STROKE/TBI Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

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